International Union of Basic and Clinical Pharmacology. CXXII. Applying an objective evaluation to the status of class A orphan G protein-coupled receptors
Year: 2026
Type: article
Abstract: ), GPR65 (protons), GPR68 (protons), GPR132 (9-hydroxyoctadecadienoic acid), GPR183 (7α,25-dihydroxycholesterol), MRGPRD (β-alanine), and MRGPRX1 (bovine adrenal medulla peptide 8-22). The issue of nomenclature for these 10 GPCRs will be considered by further subcommittees of the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology. We hope this review will prompt further investigations into these members of the currently most widely clinically exploited protein superfamily. SIGNIFICANCE STATEMENT: The use of systematic, rational nomenclature for drug targets provides a framework to ensure consistent identification and rapid recognition. Given that G protein-coupled receptors have fundamental physiological roles and are widespread targets of drugs in current clinical use, we hope the target summary and deorphanization criteria provided here will prompt renewed efforts to investigate these orphan receptors as regulators of physiology and as opportunities for future therapeutic exploitation.
Source: Pharmacological Reviews
Authors: Stephen P.H. Alexander, Kirstie A. Bennett, Andrew J. Brown, Michelle Glass, David E. Gloriam, Julien Hanson, Paul A. Insel, Eamonn Kelly, Christopher J. Langmead, Kirill A. Martemyanov, Rick R. Neubig, Stefan Offermanns, Mette M. Rosenkilde, Gunnar Schulte, Nicola J. Smith, Huixian Wu, Elena Faccenda, Simon D. Harding, Anthony P. Davenport
Institutions: University of Nottingham, Cambridge Science Centre, University of Otago, University of Copenhagen, University of Liège, University of California San Diego, University of Bristol, Monash University, University of Miami, Michigan State University, Goethe University Frankfurt, Max Planck Institute for Heart and Lung Research, Karolinska Institutet, UNSW Sydney, Pfizer (United States), University of Edinburgh, University of Cambridge, Addenbrooke's Hospital
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W7160658186