Work

Alkenyl Fluorosulfates—Expedient Partners for Palladium‐Catalyzed Cross‐Coupling Reactions

Year: 2026

Type: article

Abstract: ABSTRACT Alkenyl fluorosulfates are evaluated as the partners of palladium‐catalyzed cross‐coupling reactions and an alternative to more common triflates and halides. Efficient protocols for the multigram synthesis of title reactants using the reaction of carbonyl compounds with SO 2 F 2 were documented. Reactivity of alkenyl fluorosulfates in Suzuki, Sonogashira, Heck, Stille, and Buchwald‐Hartwig reactions, as well as Miyaura borylation under typical conditions, was studied, and limitations of the methods were established. It was found that alkenyl flurosulfates have similar or even higher reactivity in the cross‐coupling reactions as compared to alkenyl triflates.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.71098

Authors: Vladyslav Hnativ, Serhii Aleksandrenko, Serhii Zhersh, Oleksandr O. Grygorenko

Institutions: Taras Shevchenko National University of Kyiv, Enamine (Ukraine)

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Ministry of Education and Science of Ukraine, Enamine

Awards: G2979084016, G5599897042