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Comparison of Clinical Efficacy of Early Versus Delayed Laparoscopic Cholecystectomy Following Ultrasound-Guided Percutaneous Transhepatic Gallbladder Drainage

Year: 2026

Type: article

Abstract: AIM: To investigate the clinical value of early (≤7 days) versus delayed (>6 weeks) laparoscopic cholecystectomy (LC) after ultrasound-guided percutaneous transhepatic gallbladder drainage (PTGBD) in high-risk acute cholecystitis (AC), with PTGBD serving as a bridging intervention. METHODS: A retrospective analysis was performed on 110 high-risk AC patients admitted between August 2021 and January 2025. Patients were divided into an early LC group (52 cases) and a delayed LC group (58 cases). Surgical indicators, inflammatory response control, hospitalization duration, treatment costs, quality of life, and postoperative complications were compared between the two groups. RESULTS: > 0.05). CONCLUSIONS: Early LC following PTGBD effectively shortens overall treatment duration, reduces healthcare costs, and lowers surgical complexity. However, careful consideration should be given to the potential influence of residual inflammation on long-term quality of life. Further multi-center prospective studies are warranted to validate long-term safety and to optimize individualized treatment strategies.

Source: Annali Italiani di Chirurgia

DOI: 10.62713/aic.4479

Authors: Rui Liu, Guangwu Zhang, Pei Zhou, Sha Xia

Institutions: Suizhou Central Hospital, Wuhan University of Science and Technology, Huanggang Central Hospital

Language: English

Topic: Gallbladder and Bile Duct Disorders

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7160697397