Work

Voltammetric and potentiometric sensors for the detection of electrochemically inactive 2-aminoindane in saliva

Year: 2026

Type: article

Abstract: 2-Aminoindane (2-AI) belongs to new psychoactive substances and is one synthacaine component that imitates the effects of cocaine. Despite the structural similarity to amphetamine stimulants, 2-AI is electrochemical inactive. Here, 4- tert - butyl -calix[4]arene tetraacetate was applied as a recognizing component of the ion-selective membrane and modifier of the graphite electrode. The advantages and disadvantages of the direct potentiometric versus voltametric detection of 2-AI are discussed. The electrochemical selectivity and quantification in saliva samples were explained by theoretical calculations and confirmed by LC-MS experiments, respectively. Simultaneous application of both voltammetric and potentiometric sensors allows to cover the wide concentration range, specifically, 1.0 μmol L −1 up to 10 mmol L −1 . This study demonstrates the potential of the potentiometric and voltammetric detection of 2-AI as individual compound and in a mixture with other compounds in saliva (recovery 95–117%; RSD 6–15.4%), bringing an improved tool for public health protection.

Source: Results in Chemistry

DOI: 10.1016/j.rechem.2026.103418

Authors: Tatiana V. Shishkanova, František Kralík, David Sýkora

Institution: University of Chemistry and Technology, Prague

Language: English

Topic: Electrochemical sensors and biosensors

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,870