Covalent-Bond-Directed Synthesis of Rotaxanes from Macrocyclic Diaryliodonium Salts
Year: 2026
Type: article
Abstract: We achieved the synthesis of [2]rotaxane by the reaction of a bulky phenoxide with a macrocyclic iodonium salt, which served as a covalent-bond-tethered precursor. The cleavage of the tether and the formation of the axle component proceeded simultaneously, providing rotaxane in a good yield. The versatility of this approach was demonstrated by the synthesis of [3]rotaxane as well as the synthesis of [2]rotaxane from a medicine.
Source: Organic Letters
Authors: Kazushi Hamamura, Akari Nakamura, Yuichiro Mutoh, Yusuke Yoshigoe, Tairin Kawasaki, Shoichi Hosoya, Shinichi Saito
Institutions: Tokyo University of Science, Institute of Science Tokyo
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W7160715065