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Generalizability of findings from neurobiological studies of individuals with first-episode psychosis: a cohort study

Year: 2026

Type: article

Study design: Observational Study

Abstract: Using Swedish register data, we estimated the proportion of individuals with first-episode psychosis (FEP) who would be eligible to participate in a typical neurobiological study and found that only 39% met criteria. Eligible and ineligible individuals differed on sociodemographic variables and two-year outcome measures (inpatient admission, work disability). Our findings suggest that neurobiological studies may yield samples that are not fully representative of the wider FEP population, potentially limiting generalisability.

Source: Schizophrenia

DOI: 10.1038/s41537-026-00762-x

Authors: Alexis E. Cullen, Maria Lee, Pontus Josefsson, Carl M. Sellgren, Sophie Erhardt, Ellenor Mittendorfer-Rutz, Simon Cervenka

Institutions: King's College London, Karolinska Institutet, Region Stockholm, Stockholm Health Care Services, Uppsala University

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,890

Funders: Karolinska Institutet, Vetenskapsrådet

Awards: G1544513278, Psychosis early detection and intervention strategies in Sweden: Evaluating potential impact and developing predictive and prognostic models to aid implementation, REWHARD - National infrastructure for research about social relations, work and health across the life course

OpenAlex ID: W7160725261

FWCI:

Cites: 9

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