Work

Research Progress of Cuproptosis in Orthopaedics: Opportunities and Challenges

Year: 2026

Type: article

Abstract: Cuproptosis, a recently identified and copper-dependent form of regulated cell death, has emerged as a potential therapeutic target for a variety of diseases. This review synthesizes current evidence from PubMed to elucidate the mechanisms of cuproptosis and its implications in common orthopaedic disorders, including arthritis, bone tumours and osteoporosis. We systematically explore the dual role of copper homeostasis-highlighting how its dysregulation contributes to disease pathogenesis and how its targeted modulation may offer novel therapeutic strategies. Finally, we discuss the associated challenges and future directions for translating cuproptosis research into clinical orthopaedics practice.

Source: Journal of Cellular and Molecular Medicine

DOI: 10.1111/jcmm.71175

Authors: Chaoshuai Wang, Pengfei An

Institutions: Shandong University of Traditional Chinese Medicine, Weinan Central Hospital

Language: English

Topic: Trace Elements in Health

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,210