Work

Purpuric Patches as Cutaneous Presentation of Pediatric NTRK ‐Rearranged Spindle Cell Neoplasm

Year: 2026

Type: article

Abstract: Neurotrophic tyrosine receptor kinase-rearranged spindle cell neoplasms (NTRK-RSCNs) are rare soft tissue tumors with a broad histologic spectrum. Limited data exist on their cutaneous manifestations, particularly in pediatric patients. We present the case of a 4-year-old girl with an LMNA-NTRK1 fusion-positive spindle cell neoplasm initially presenting as a subcutaneous nodule adjacent to purpuric patches on the abdomen. This case highlights an atypical cutaneous presentation of NTRK-RSCNs and demonstrates the successful use of larotrectinib, a TRK inhibitor, in achieving both clinical and histological remission.

Source: Pediatric Dermatology

DOI: 10.1111/pde.70230

Authors: Sarah S. Lee, Birgitta A. R. Schmidt, Brent R. Weil, Pierre‐Olivier Grenier

Institutions: Harvard University, Boston Children's Hospital

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7160762817