Work

Microsurgical Onco‐Testicular Sperm Extraction in a Patient With Testicular Cancer and Congenital Unilateral Testicular Absence: A Case Report

Year: 2026

Type: article

Abstract: Introduction: Testicular cancer primarily affects men of reproductive age. Therefore, fertility preservation is important in managing testicular cancer. In patients with a solitary testis, oncological testicular sperm extraction (onco-TESE) is used to retrieve sperm from tumor-bearing testis. Case Presentation: A 39-year-old man with congenital absence of the left testis presented with a 4-month history of progressive right testicular swelling. Laboratory tests showed elevated β-human chorionic gonadotropin and follicle-stimulating hormone concentrations, and ultrasonography showed a heterogeneous hypoechoic mass with microcalcifications. A seminal analysis showed azoospermia with AZFc partial deletion. Following orchiectomy, microsurgical onco-TESE was performed. Motile sperm were successfully retrieved from preserved seminiferous tubules. A pathological examination demonstrated a pure seminoma. In preserved seminiferous tubules, the Johnsen score was 9-10, and partial tubular hyalinization and microcalcifications were observed. Conclusion: Microsurgical onco-TESE is for retrieving sperm in patients with testicular cancer with a solitary testis, even in the presence of impaired spermatogenesis.

Source: IJU Case Reports

DOI: 10.1002/iju5.70191

Authors: Yuki Matsumoto, Toshiyasu Amano, Mamoru Hachiya, Tomohisa Fujita, Tetsuya Imao

Institution: Nagano Red Cross Hospital

Language: English

Topic: Sperm and Testicular Function

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,960