Work

Unveiling trends in malignant neoplasms of bone and articular cartilage mortality in the United States (1999–2023): a CDC WONDER perspective

Year: 2026

Type: article

Abstract: Background: Malignant neoplasms of bone and articular cartilage (MNBAC) are rare but highly fatal cancers contributing to global cancer mortality. This study analyzed demographic and regional patterns of MNBAC mortality in the United States from 1999 to 2023 to identify high-risk populations for targeted interventions. Methods: We extracted mortality data from the CDC WONDER database using ICD-10 codes C40-C41. Crude and age-adjusted mortality rates (AAMRs) per 100,000 population were calculated by gender, census region, race, and urbanization using R software (version 4.4.2). Joinpoint regression was employed to evaluate annual percentage changes (APCs). Results: ). Overall AAMR increased marginally from 2014 to 2018 (APC = 4.26, 95% CI: 0.00 to 8.69) before stabilizing.Figure 1The trend of AAMRs stratified by gender. The * denotes the APC that was found to be statistically at α= 0.05.Line graph showing age-adjusted mortality rates (AAMR) per one hundred thousand population from 1999 to 2023, separated by sex: male (blue), female (green), and both (red). Males consistently have higher rates, females lower, and both combined are intermediate. Shaded regions represent confidence intervals. Key inflection points and annual percent changes (APC) for each group are noted below the graph, indicating periods of increase and decline. Conclusion: Significant disparities exist in MNBAC mortality, with elevated rates among males, Southerners, and non-Hispanic whites. Notable increases occurred in the West, among those aged ≥75 years, Hispanics, and metropolitan residents. These findings underscore the need for targeted interventions to improve outcomes and reduce mortality.

Source: Frontiers in Oncology

DOI: 10.3389/fonc.2026.1748685

Authors: Bo Chen, Xiangyi Li

Institution: Changzhi Medical College

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Reduced inequalities

Open Access status: gold

Estimated APC paid: $3,801