Real-life data on the use of three-weekly versus weekly cisplatin concomitant with radiotherapy in the locoregional treatment of patients with head and neck squamous cell carcinoma
Year: 2026
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: The choice of cisplatin regimen concomitant with radiotherapy (CRT) has been a matter of debate in recent years. In the adjuvant setting, the phase III JCOG 1008 trial has demonstrated non-inferiority of the weekly dose (qW) regimen in terms of overall survival. In the radical setting, the phase III ConCERT trial did the same in terms of 2-year local control rate. However, data from the 6-year results of the phase III clinical trial by Noronha et al. (adjuvant setting) and the meta-analysis conducted by Zhu, J. et al. (2012) (radical setting) positions the three-weekly (q3W) regimen as superior. MATERIAL AND METHODS: This was a retrospective, descriptive, comparative observational non-inferiority study (δ = 10%). We analyzed data from 58 patients with HNSCC treated with CRT (36 q3W, 22 qW; 44.8% adjuvant setting and 53.4% radical setting) between January 2019 and December 2023. Patients in the qW arm were less fit than those treated with q3W in our sample. RESULTS: We found no difference in median cumulative cisplatin dose or in G3 toxicity rate. With a median follow-up of 27 months (q3W) and 14 months (qW), the recurrence, progression, or exitus rate was 19.4%, 22.2%, and 25% (q3W) vs. 13.6%, 18.2%, and 18.2% (qW). No significant differences were found in the Kaplan-Meier survival estimates (long-rank test p: local/distant-DFS = 0.93; PFS = 0.91; OS = 0.71). CONCLUSIONS: Tolerability and compliance of the qW regimen in a less fit patient population was similar to that of the fitter q3W patients. No differences were found in DFS, PFS, and OS.
DOI: 10.5603/ocp.103305
Authors: Irene Bannenberg Cavero, Elia Martínez Moreno, David Gutiérrez Abad, Carlos de Zea Luque, Fatima Escalona Martín, Isabel Santana Gómez, Gadea Ruíz Diez, Ana Manuela Martín Fernández de Soignie, Begoña Caballero Perea, Soraya Marcos Sánchez, Lucía Paisán Palacio, Virginia García-Jarabo, Blanca Ludena Martínez, Juan Antonio Guerra Martínez, Irene Solana López
Institution: Hospital Universitario de Fuenlabrada
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7160773320
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