Dysfunctional Brain Circuits Overlap in Lesional and Idiopathic Obsessive-Compulsive Disorder
Year: 2026
Type: article
Abstract: BACKGROUND: Obsessive-compulsive disorder (OCD) may develop following brain lesions, but lesion distribution and connectivity patterns are unknown. METHODS: Cases of OCD associated with focal brain lesions were identified using a systematic literature search and compared with control lesions (n = 608). Connectivity with each lesion location was computed using normative functional connectivity (n = 1000), and a network specific to OCD lesions was identified. The relevance of this network for primary OCD was explored. RESULTS: Among 129 cases of lesion-associated OCD, 40 had clearly defined locations. OCD-associated lesions intersected the orbitofrontal cortex and right temporal pole more than control lesions and were associated with connectivity to a distinct brain network. This network overlapped with abnormal functional brain imaging and with effective brain stimulation targets in primary OCD. CONCLUSIONS: Lesion locations associated with OCD map to a common brain network that aligns with brain imaging abnormalities and brain stimulation outcomes in patients with primary OCD.
Source: Biological Psychiatry
Institutions: Champalimaud Foundation, Universidade Nova de Lisboa, Hospital Garcia de Orta, University of Lisbon, Instituto Superior Técnico, Laboratório de Robótica e Sistemas de Engenharia, Hospital de Egas Moniz, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental, Harvard University, Massachusetts General Hospital, Brigham and Women's Hospital
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: hybrid
Estimated APC paid: $5,489
Funders: Brain and Behavior Research Foundation, Sidney R. Baer, Jr. Foundation, Nancy Lurie Marks Family Foundation, National Alliance for Research on Schizophrenia and Depression, G. Harold and Leila Y. Mathers Foundation, BrainsWay, European Commission, Ministerio de Economía y Competitividad, Ministério da Ciência, Tecnologia e Ensino Superior, National Institutes of Health, McDonnell Center for Systems Neuroscience, Horizon 2020 Framework Programme, European Research Council, Fundação para a Ciência e a Tecnologia, European Regional Development Fund, National Institute on Aging, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, NIH Blueprint for Neuroscience Research, H2020 European Research Council
Awards: G1077381383, G1516346500, Targeted modulation of symptom-specific brain circuits with transcranial magnetic stimulation, a Federated Artificial Intelligence solution for moniToring mental Health status after cancer treatment, Reinforcement learning from post-ingestive calories: from body to brain in health and disease, G3798018224, G3908588039, G4014141827, G4523758919, Reinforcement learning from post-ingestive calories: from body to brain in health and disease, G5454278309, Childhood trauma functional connectivity correlates in patients with obsessive-compulsive disorder, Transdiagnostic memory, mood and motor circuits in Alzheimer's and neurodegenerative disease, G6672651208, Identifying neuromodulation targets for pain in the human brain, Immune dysfunction in obsessive-compulsive disorder: from environmental risk factors to clinical and brain imaging correlates, G7184972784, G743645930, G8299918676, G8607804820, G8790201707, Perturbação obsessivo-compulsiva e aprendizagem pelo reforço: explorando o papel do cortex orbitofrontal, G9000089182, G9000360988, Using human brain connectivity to identify the causal neuroanatomical substrate of depression symptoms, G9001170305, G9001170425, G946021960
OpenAlex ID: W7160820330