Work

Orbital and Parotid Metastases from Nasopharyngeal Carcinoma: A Rare Case Presentation and Review of the Literature

Year: 2026

Type: article

Abstract: Introduction: Nasopharyngeal carcinoma (NPC) is a rare, yet aggressive malignancy characterized by various clinical presentations. Metastasis to the orbital and parotid regions presents diagnostic challenges and adds complexity to the management. Case Presentation: Herein, we present a case of a 23-year-old male diagnosed with non-keratinizing undifferentiated NPC, initially presenting with orbital metastasis followed by parotid gland involvement shortly after completion of chemoradiotherapy. The patient underwent surgical intervention preceded by chemoradiotherapy, resulting in complete remission without recurrence over a 12-month follow-up period. Conclusion: This case reinforces the critical importance of vigilant long-term surveillance in high-risk NPC patients with symptom-directed and risk-adapted surveillance approaches.

Source: Case Reports in Oncology

DOI: 10.1159/000551478

Authors: Shmokh Alsalamah, Sultan Alsumairi, Malak AlMalki, Majed Pharaon, Mohammed Alessa

Institutions: King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, National Guard Health Affairs, King Saud University

Language: English

Topic: Head and Neck Cancer Studies

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,170