Test of the reward/circadian rhythm dysregulation model of risk for bipolar spectrum disorders at a micro time scale using multilevel moderated mediation.
Year: 2026
Type: article
Study design: Observational Study
Abstract: = 145) with high- or moderate-reward sensitivity across 20-days of ecological momentary assessment. Significant interaction effects were observed such that high-reward individuals experienced more reward-relevant life events and associated SRD. Moderated mediation analysis supported the integrated model at the daily level for depressive symptoms. For hypomanic symptoms, there was not a significant indirect effect nor moderation by reward group. Findings suggest hypersensitivity to reward amplifies the effects of reward-relevant life events on SRD, contributing to the onset of depressive symptoms in individuals at-risk for BSD. Results highlight potential early intervention targets. (PsycInfo Database Record (c) 2026 APA, all rights reserved).
DOI: 10.1037/abn0001127
Institutions: Temple University, Rush University Medical Center
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: National Institutes of Health
Awards: Impact of Daytime vs. Delayed Eating Schedule on Weight and Metabolic Markers Among Obese Persons: An Examination of Circadian Mechanisms, Social and Circadian Rhythms, Reward Sensitivity, and Risk for Bipolar Disorder, Risk for Bipolar Disorder: Reward-related Brain Function & Social Rhythms, Integrated Reward-Circadian Rhythm Model of First Onset of Bipolar Spectrum Disorders in Adolescence
OpenAlex ID: W7160823233
FWCI:
Cites:
Cited by:
Related to: