Work

Relative contributions of mitochondrial and nonmitochondrial oxidative stress in age-related cutaneous microvascular endothelial dysfunction

Year: 2026

Type: article

Abstract: Age-related declines in nitric oxide-mediated cutaneous microvascular function are due, at least in part, to increased oxidative stress. However, the specific sources of oxidative stress that contribute to microvascular endothelial dysfunction with aging remain unclear. Here, we demonstrate that, although mitochondrial oxidative stress may contribute, a considerable portion of the oxidative stress underlying age-related endothelial dysfunction is derived outside of the mitochondria.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00256.2026

Authors: William E. Jennings, James F. Bangle, Georgia R. Davila, S. Tony Wolf

Institutions: University of Georgia, Indiana University

Language: English

Topic: Nitric Oxide and Endothelin Effects

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7160823320