Work

Electrochemical Skeletal Editing via Manganese‐Catalyzed Nitrogen Atom Insertion Scalable by Electroflow

Year: 2026

Type: article

Abstract: Molecular editing and atom insertion are powerful tools for the late‐stage construction of complex molecular architectures, especially in medicinal chemistry. However, up to now, such transformations rely on harsh conditions and superstoichiometric chemical oxidants. Although electrochemical strategies for skeletal editing strongly mitigate some of these constraints, the substrate scope remains narrow. Moreover, the use of hazardous reagents in high concentrations severely limits the applicability of these strategies for scale‐up and subsequent industrial application. To overcome these bottlenecks, we herein present a manganaelectro‐catalyzed nitrogen atom insertion furnishing isoquinolines with broad functional group tolerance. Furthermore, our approach also proved suitable for recirculation flow electrolysis, including scale‐up, reflecting its potential for industrial application.

Source: ChemistryEurope

DOI: 10.1002/ceur.70305

Authors: Simon L. Homölle, Tristan Bauch, Aboubakr Hamad, Bo‐Sheng Zhang, Lutz Ackermann

Institution: University of Göttingen

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: Deutsche Forschungsgemeinschaft, European Research Council

Award: G1538027843