Enabling Base‐Free Direct C–H Arylation of Thiophene Derivatives: Glycerol‐Derived Solvents as Active Reaction Media
Year: 2026
Type: article
Abstract: Nonvolatile glycerol derivatives are employed as effective reaction media for the Pd-catalysed direct CH arylation of 3,4-ethylenedioxythiophene and other thiophenes. The thoughtful design of noninnocent glycerol-derived ionic liquids (ILs) allows them to act simultaneously both as solvent and base, eliminating the need for an additional base and thus improving the sustainability of the process. Moreover, the stabilization of palladium nanoparticles in the task-specific solvent offers an excellent approach by providing the advantages of a homogeneous, selective, and recoverable catalytic system. This multifunctional behaviour highlights the potential of glycerol-derived ILs as sustainable solvents and promoters for transition metal-catalysed CH activation reactions.
Source: ChemSusChem
Institutions: Consejo Superior de Investigaciones Científicas, Universidad de Zaragoza, Instituto de Síntesis Química y Catálisis Homogénea, Institute of Science, Technology and Sustainability for Ceramics, National Interuniversity Consortium of Materials Science and Technology, University of Turin, Sapienza University of Rome
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,550
Awards: G1303340219, G1671838063, G1941997073, G231133531, G2619993990, G2929079224, G349346387, G3578194056, G399101681, G4651782828, G4897547097, G5128794505, G5416967273, Catálisis Heterogénea en Síntesis Orgánicas Selectivas, G598502428, G6341469117, G6360694085, G640733617, G683883107, G7434936867, G858891212, G972786147
OpenAlex ID: W7160831909