Myocardial relaxation, left ventricular filling, and exercise capacity in older subjects with dyspnea
Year: 2026
Type: article
Abstract: Dyspnea in older subjects and patients with HFpEF is usually attributed to elevated LV filling pressures caused by reduced end-diastolic compliance. This study demonstrates that during exercise, slow early diastolic relaxation and reduced ventricular suction limit increments in early diastolic filling and impair stroke volume reserve, thereby reducing exercise capacity. Lowering late systolic pressure and augmenting early diastolic filling may be important targets for pharmacologic therapy to reduce dyspnea.
Institutions: Castle Hill Hospital, University College London, Institució Catalana de Recerca i Estudis Avançats, Universitat Pompeu Fabra, KU Leuven, Università degli Studi del Piemonte Orientale “Amedeo Avogadro”, St Bartholomew's Hospital, Queen Mary University of London, University Hospital of Wales, Cardiff University
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Award: G7342731343
OpenAlex ID: W7160832483