Evaluation of surgical stress after colorectal interventions: a multicenter randomized clinical trial of robotic versus laparoscopic surgery
Year: 2026
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: A major factor in the development of morbidity after surgery is the surgical stress response. The aim of this interventional multicenter randomized open label, parallel group trial is to evaluate the possible lower inflammatory stress response induced by robot-assisted versus laparoscopic surgery for colorectal resections. A total of 593 patients diagnosed with colorectal cancer planned for elective, curative surgery was screened for eligibility. 314 patients planned for right colectomy, left colectomy or rectal resection were randomly assigned 1:1 to robotic (n = 161) or laparoscopic group (n = 153). The primary endpoint was the 24-hours postoperative ∆% change of IL-6 serum levels. Subgroup analyses included the assessment of IL-6 ∆% changes stratified according to age, obesity, comorbidities, tumor staging and resection type have been also performed. In conclusion robotic surgery was associated to a lower surgical stress after colorectal surgery and this finding may help in decision-making regarding when to proceed to robotic approach for colorectal cancer, especially in selected high risk clinical settings.
Source: Scientific Reports
Authors: Marco Milone, Sara Vertaldi, Pietro Anoldo, Simona Borin, Ilenia Calcaterra, Michele Campitelli, Graziano Ceccarelli, Anna D’Amore, Maurizio Degiuli, Paolo Delrio, Fatima Domenica Elisa De Palma, Matteo Nicola Dario Di Minno, Uberto Romario Fumagalli, Mario Guerrieri, Michele Manigrasso, Monica Ortenzi, Ugo Pace, Felice Pirozzi, Lucia Puca, Wanda Petz, Rossella Reddavid, Daniela Rega, Gregory Alexander Raciti, Fabio Rondelli, Antonio Sciuto, Antonella Desiderio, Giovanni Domenico De Palma
Institutions: Federico II University Hospital, University of Naples Federico II, European Institute of Oncology, University of Perugia, Ospedale San Luigi Gonzaga, University of Turin, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Marche Polytechnic University, Ospedale Antonio Cardarelli
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
OpenAlex ID: W7160835864