Work

Obesity in Classic Congenital Adrenal Hyperplasia: Mechanisms, Complications and Management

Year: 2026

Type: article

Abstract: Classic congenital adrenal hyperplasia (CCAH) is an autosomal recessive genetic disorder primarily caused by 21-hydroxylase deficiency. Although the survival rate of patients has significantly improved with glucocorticoid replacement therapy, long-term use of supraphysiological doses and multiple factors inherent to the disease itself have led to obesity becoming a common metabolic complication in CCAH patients. The mechanism of obesity in CCAH patients is complex and involves multiple factors related to both treatment and the disease itself. This article provides a narrative review of the incidence, influencing factors, related complications and treatment management strategies of obesity in CCAH patients, with the aim of offering comprehensive management recommendations for clinical practice.

Source: Clinical Endocrinology

DOI: 10.1111/cen.70155

Authors: Jialin Mu, Yue Li, Meng Sun, Yulin Li, Panpan Li, Hui Zou

Institutions: Jinan Maternity And Care Hospital, Shandong Provincial QianFoShan Hospital, Shandong First Medical University

Language: English

Topic: Sexual Differentiation and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,250