Work

Interval‐Partial Least Squares to Eliminate Spectral Moisture Interference in Near Infrared Transmission Quantification of the Active Pharmaceutical Ingredient in Escitalopram Tablets

Year: 2026

Type: article

Abstract: ABSTRACT Near infrared spectroscopy is a technique commonly applied to pharmaceutical tablets to quantify the active pharmaceutical ingredient (API). During its lifetime, the tablet product may absorb water, which can result in deteriorating performance of the initial calibration model. However, through variable subset reduction, it is possible to avoid the spectral interference from water uptake in the tablets. Calibration models based on samples with lower water uptake were used to predict samples with higher water uptake. Reducing the wavelength range to only the range for which the API absorbs resulted in a prediction error of 0.27% (w/w) compared with the prediction error of 0.29% (w/w) for the full spectral range.

Source: Journal of Chemometrics

DOI: 10.1002/cem.70134

Authors: Åsmund Rinnan, Solveig Warnecke, Morten Allesø, Søren B. Engelsen

Institutions: University of Copenhagen, Novo Nordisk (Denmark)

Language: English

Topic: Spectroscopy and Chemometric Analyses

Subfield: Analytical Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,710