Work

Base-Promoted C→N Carbonyl Shift Enables One-Step Access to aza-β-Lactams from α-Heteroaryl-α-amino Esters

Year: 2026

Type: article

Abstract: -substituents. Isolation and productive re-entry of a carbamate intermediate support a reversible manifold preceding migration and rationalize racemic product formation.

Source: Organic Letters

DOI: 10.1021/acs.orglett.6c01451

Authors: Jozef Kristek, Nikola Št’astná, Jiří Pospíšil

Institutions: Palacký University Olomouc, Czech Academy of Sciences, Institute of Experimental Botany

Language: English

Topic: Synthesis of β-Lactam Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Univerzita Palackého v Olomouci, European Regional Development Fund

Awards: G3209139373, G700906286

OpenAlex ID: W7160857779

FWCI:

Cites: 24

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