Work

Clinical screening and peer interventions to prevent substance use in at-risk adolescents: A longitudinal single-arm trial protocol

Year: 2026

Type: article

Abstract: Background: Mental health conditions and substance use disorders commonly co-occur and adolescence is a period of increased risk for both. Adolescents with mental health conditions often begin using substances earlier than those without. Early initiation increases the risk of later substance use disorder. We propose to measure the impact of a peer-developed, primary care-based intervention to prevent substance use initiation among adolescents with mental health diagnoses and to evaluate responses to the intervention. Methods: This is a single-arm 12-month longitudinal unblinded pilot observational study. Adolescents aged 11-14 receiving pediatric primary care for diagnoses of depression, anxiety, or ADHD who have not yet initiated substance use will be eligible. The intervention involves quarterly assessments of substance use in the primary care office followed by viewing one of four 90-s videos targeting prevention topics like peer pressure for those who remain substance-free. The primary outcome is time to substance initiation, measured using the validated CRAFFT 2.1+N screener. Secondary outcomes include participant acceptance of the intervention, assessed by surveys, and tertiary outcomes will describe characteristics of participants who initiate substance use during the study. Analysis: We will use Kaplan-Meier survival estimates and descriptive statistics. Subgroup analyses will include age, sex, and diagnosis. Discussion: This trial targets a vulnerable population with increased risk for future substance use disorder. The intervention seeks to harness the protective effects of positive peer influence within the context of ongoing patient-provider relationships to promote delayed onset of substance use and inform feasibility and design of a future multi-site trial.

Source: Contemporary Clinical Trials Communications

DOI: 10.1016/j.conctc.2026.101647

Authors: Gail L. Rose, Michelle Shepard, Derek Devine, Christine Gallese, Constance van Eeghen

Institutions: University of Vermont, University of Vermont Medical Center

Language: English

Topic: Substance Abuse Treatment and Outcomes

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,320