Expanding PPMI through Remote Data Acquisition and Analysis: Early Success and Future Growth with myPPMI
Year: 2026
Type: article
Abstract: The creation and ongoing development of the myPPMI platform (see Stanley et al in this issue), has enabled the Parkinson's Progression Markers Initiative (PPMI) to expand our research efforts to acquire additional data, engage a large number of participants, and reduce participant burden to enable long-term follow-up. We now review specific virtual and remote studies and sub-studies including Found, PPMI Online, and PPMI Cognitive that PPMI has developed to enhance participant engagement and enable remote data collection. FOUND in PPMI was initiated before myPPMI and continues to serve as a model for remote participant engagement. FOUND maintains longitudinal contact, reducing study attrition, and preserving data continuity. PPMI Online, now part of myPPMI, enables low-burden, participant-reported data collection, reduces geographic barriers, and enables sub-studies of less common subgroups. Cognitive testing is another study within myPPMI to assess longitudinal cognition. myPPMI, a global web-based portal, introduces precision recruitment, real-time eligibility matching, and inclusive design. Together, these innovations enable remote and hybrid recruitment and study conduct, reduce logistical and economic barriers, and advance scalable, participant-centered research to transform the landscape of Parkinson's disease studies across populations. ANN NEUROL 2026.
Source: Annals of Neurology
DOI: 10.1002/ana.78245
Authors: Caroline M. Tanner, Craig E. Stanley, Ethan G. Brown, Lana M. Chahine, Daniel Weintraub, Roseanne D. Dobkin, Werner Poewe, Eduardo Tolosa, Connie Marras, Sebastian Schade, Kelvin L. Chou, Nicola Pavese, Christopher S. Coffey, Michael C. Brumm, Ryan Kurth, Alastair J. Noyce, Paulina Gonzalez‐Latapi, Auldyn Matthews‐McGee, Monica Korell, Cheryl Meng, Xuejie Chen, Lynn Racelo, Jillian Ricci, Cailey Fitzgerald, Nichole H. Rigby, John A. Battles, Jacqueline K. Carley, Zeina Singh, Laura Kruchkow, Bridget A. McMahon, Emily Flagg, Lynell P. Lemon, John‐Michael Talarico, Kathryn Brodkin, Christina Destro, Maggie McGuire Kuhl, Kimberly Fabrizio, Kenneth Marek, Thomas F. Tropea, Parkinson's Progression Markers Initiative
Institutions: University of California, San Francisco, Institute for Neurodegenerative Disorders, University of Pittsburgh, University of Pennsylvania, Rutgers, The State University of New Jersey, Innsbruck Medical University, Universität Innsbruck, Biomedical Research Networking Center on Neurodegenerative Diseases, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona, University Health Network, University of Toronto, Universitätsmedizin Göttingen, Paracelsus Elena Klinik Kassel, University of Michigan, Newcastle University, University of Iowa, Queen Mary University of London, Northwestern University, Michael J. Fox Foundation
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7160868207