Work

Emerging digital platforms for precise and ultrasensitive biosensing

Year: 2026

Type: article

Abstract: Digital biosensing has emerged as an irreplaceable, ultrasensitive biosensing method across research and clinical diagnosis. The frontier leap achieved by partitioning target molecules into individual units, reaching single-molecule-level sensitivity, pioneers a new biosensing direction. This review summarizes the fundamental principles, the biosensing performance, the methodological limitations, and the future opportunities of emerging digital platforms integrated with different signal output modes, particularly including fluorescence, Raman scattering, electrochemistry, and particle motion.

Source: npj Biosensing

DOI: 10.1038/s44328-026-00102-0

Authors: Wenjiao Fan, Yuanyuan Dong, Jingjing Shi, Chao Lei, Wei Ren, Chenghui Liu

Institution: Shaanxi Normal University

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $2,590

Funders: National Natural Science Foundation of China, Shaanxi Province Postdoctoral Science Foundation, Fundamental Research Funds for the Central Universities, Program for Changjiang Scholars and Innovative Research Team in University