Work

SLC16A1 lactylation links epimetabolic reprogramming of triglycerides (50:3 and 50:1) to blood pressure regulation

Year: 2026

Type: article

Abstract: Objective This study aims to investigate the causal relationship between SLC16A1 lactylation modification and systolic blood pressure (SBP) and diastolic blood pressure (DBP), as well as the potential mediating role of lipidomics-triglyceride (50:3/50:1) in this association. Methods This study combines eQTL data and lactylation modifications to identify 16 associated genes, using Mendelian randomisation (MR) to assess their effects on SBP and DBP. It also employs summary-data-based Mendelian randomisation (SMR) for validation and lipidomics analysis to explore the effect of SLC16A1 lactylation on triglyceride (TG) subtypes (50:3/50:1). Finally, mediation analysis quantifies the role of triglyceride subtypes in the link between SLC16A1 lactylation and blood pressure changes. Results SLC16A1 lactylation modification negatively correlates with SBP ( β = -1.181, P < 0.001) and DBP ( β = -0.9954, P < 0.001), confirmed by SMR analysis ( P < 0.001). Lipidomics shows TG(50:3) and TG(50:1) are crucial for SBP and DBP, with TG(50:3) mediating 11.32% of the effect on SBP ( P = 0.0381) and TG(50:1) mediating 9.32% on DBP ( P = 0.00066). Conclusion This study reveals that SLC16A1 lactylation modification might regulate SBP and DBP by suppressing the levels of TG(50:3) and TG(50:1), offering potential therapeutic targets for precision interventions in metabolic hypertension.

Source: SAGE Open Medicine

DOI: 10.1177/20503121261451329

Authors: Weikun Zhao, Xiaoping Li, Rongjie Huang, Zuchun Luo

Institutions: Guilin Medical University, First Affiliated Hospital of GuangXi Medical University

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,000