Pharmaceutico-analytical Evaluation of Drakshadi Gutika and a Novel Polyherbal Tablet with Comparative Assessment of Antioxidant Activity and Acid-neutralising Capacity: A Research Protocol
Year: 2026
Type: article
Study design: Study Protocol
Abstract: Introduction: Polyherbal formulations are an essential element of traditional medicine systems, particularly Ayurveda, due to the synergistic effects produced by the combination of multiple plant-derived ingredients. Drakshadi Gutika is a well-known Ayurvedic formulation primarily used to enhance digestion and address gastrointestinal disorders. In contrast, the Novel Polyherbal Tablet (NPT) will be a contemporary multi-herb-based formulation designed to address similar therapeutic indications. Both formulations are believed to possess antioxidant and acid-neutralising properties, which will be crucial for managing oxidative stress and gastric acidity, respectively.The study intends to provide a scientific basis for their quality control and therapeutic potential. Need of the study: Stress is a major cause of hyperacidity, affecting 60–70% of individuals. This study introduces a Novel Polyherbal Tablet formulated with proven antioxidant and antiulcer herbs to evaluate its synergistic antioxidant and acidneutralising effects compared to Drakshadi Gutika. Due to the impracticality of Drakshadi Gutika’s classical 12 g dosage, a modified, formulation is proposed. Aim: To evaluate and compare the pharmaceutico-analytical properties, antioxidant activity and acid-neutralising capacity of Drakshadi Gutika and the Novel Polyherbal Tablet. The study intends to provide a scientific basis for their quality control and therapeutic potential. Materials and Methods:This experimental analytical study will take place from July 2025 to November 2025 at the Biocyte Research and Development Pvt Ltd., Sangli. Both Drakshadi Gutika and NPT will be procured from authenticated sources and their ingredients will be identified and analysed for Standardisation. The pharmaceutico-analytical assessment included evaluations of organoleptic properties (colour, taste, odour), moisture content, total ash and loss on drying, as well as dissolution profiles. For antioxidant activity, the 2, 2-diphenyl-1- picrylhydrazyl (DPPH) free radical scavenging assay will be employed to determine the antioxidant potential of both formulations. The acid-neutralising capacity of each formulation will be measured through titration with a standardised acid solution, calculating the buffering capacity against simulated gastric acid. Statistical analysis will be performed to compare the results of both formulations with respect to antioxidant activity and acid-neutralising capacity will be compared by using statistical analysis by applying Unpaired t-test.
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $275
OpenAlex ID: W7160889181
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