Work

Design, synthesis, and antiproliferative activity of novel thiazole-based derivatives as tubulin polymerization inhibitors targeting the colchicine binding site

Year: 2026

Type: article

Abstract: ADMET predictions further supported 9k as a drug-like lead with acceptable oral exposure and a beneficial P-gp-related transporter profile. The enhanced apoptotic effects of 9k compared with Staurosporine make 9k an attractive lead candidate for further development as an anti-cancer drug targeting the colchicine-binding site.

Source: RSC Advances

DOI: 10.1039/d6ra01355d

Authors: Lamya H. Al-Wahaibi, Ali M. Elshamsy, Taha F. S. Ali, Bahaa G. M. Youssif, Stefan Bräse, Mohamed Abdel-Aziz, Nawal A. El-Koussi

Institutions: Princess Nourah bint Abdulrahman University, Deraya University, Minia University, Assiut University, Karlsruhe Institute of Technology

Language: English

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042

Funders: Karlsruhe Institute of Technology, Princess Nourah Bint Abdulrahman University

Award: G1925486399

OpenAlex ID: W7160937624

FWCI: 1.497

Cites: 46

Cited by: 1

Related to: 10