Effect of remote ischemic conditioning on prognosis and serum Maresin 1 levels in patients with acute ischemic stroke
Year: 2026
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Objective To investigate the effects of remote ischemic conditioning (RIC) on clinical outcomes and serum Maresin 1 (MaR1) levels in patients with mild‑to‑moderate acute ischemic stroke (AIS) who did not undergo vascular recanalization.Methods This study included 104 AIS patients treated beyond the thrombolytic window at Bengbu First People’s Hospital (March 2023–September 2024). They were randomly assigned to RIC (n = 50, RIC plus conventional treatment) or control (n = 54, conventional treatment alone). Modified Rankin Scale (mRS), NIH Stroke Scale (NIHSS) scores, and MaR1 levels were assessed.Results At 90 days, the proportion of patients with mRS 0‑2 was significantly higher in the RIC group (p < 0.05). No deaths occurred; cerebral hemorrhage was seen in one control patient (1.9%) but none in the RIC group (p > 0.05). NIHSS scores improved progressively in both groups at 14, 30 and 90 days, with significantly greater improvement in the RIC group (p < 0.05). At 14 days, MaR1 levels in the RIC group were significantly increased from baseline (p < 0.01) and were significantly higher than in controls (p < 0.05). Moreover, MaR1 levels correlated inversely with NIHSS (r=−0.472) and mRS (r =−0.535) scores (both p < 0.001).Conclusion In AIS patients not receiving vascular recanalization, RIC therapy significantly improves neurological recovery and reduces disability. This neuroprotective effect may be mediated in part by upregulation of MaR1.
Source: Neurological Research
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7160965363