Work

Inside the Heterogeneity of Primary CNS Vasculitis

Year: 2026

Type: article

Abstract: BACKGROUND AND OBJECTIVES: Primary CNS vasculitis (PCNSV) is a heterogeneous condition. This study examines a large cohort with long-term follow-up to identify potential disease subsets. METHODS: We retrospectively analyzed 216 patients with PCNSV (Mayo Clinic, 1983-2023), using standardized diagnostic criteria, classifying by vessel size, histopathology, and outcomes. Subsets and predictors of functional and therapeutic outcomes were evaluated. RESULTS: = 0.03). DISCUSSION: PCNSV heterogeneity, driven by vessel size and histology, affects presentation and outcomes; our findings offer insights to improve diagnosis and treatment.

Source: Neurology Neuroimmunology & Neuroinflammation

DOI: 10.1212/nxi.0000000000200573

Authors: Carlo Salvarani, Gene G. Hunder, Teresa Christianson, John Huston, Caterina Giannini, Robert D. Brown

Institutions: University of Modena and Reggio Emilia, Mayo Clinic, Azienda Sanitaria Unità Locale di Reggio Emilia

Language: English

Topic: Vasculitis and related conditions

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,450