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Inflammation as an Etiologic Agent of Gastric Cancer.

Year: 2026

Type: article

Abstract: . We and others have shown that atrophy can also be induced by the secreted immune products (cytokines) of a type I/Th1 or Th17 immune response. The atrophic phase of gastritis is superseded by a metaplastic, or cellular redifferentiation phase driven by type II (Th2) cytokines. The outcome of this inflammatory sequela is dysplasia of the gastric epithelium; the substrate for multiple types of gastric cancers. Here we summarize our recent findings on Th1/Th17 and Th2 immune responses and their roles in driving gastric atrophy, metaplasia, and carcinogenesis. Importantly, these cytokines and their receptors represent promising therapeutic targets for the prevention and treatment of gastric cancer.

Source: PubMed

Authors: Javier A Carrero, Melody Zhang, Richard J DiPaolo

Institution: Saint Louis University

Language: English

Topic: Helicobacter pylori-related gastroenterology studies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7161089573

FWCI:

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