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The Interplay of Aging and the Immune System.

Year: 2026

Type: article

Abstract: Aging is a genetically regulated biological process. We review recent studies that highlight the role of the immune system, specifically chronic inflammation, in contributing to age-related decline and frailty. Of clinical importance, aging is a risk factor for multiple conditions. During childbearing years, women are largely protected from diseases associated with aging. However, menopause, which marks the loss of ovarian function, introduces a significant shift. An unexpected and remarkable discovery is that the decline in estrogen levels triggers chronic inflammation, which in turn promotes atherosclerosis, osteoporosis, and cognitive decline. Gaining a deeper understanding of the crosstalk between aging and the immune system is essential for advancing strategies that support healthy aging.

Source: PubMed

Authors: Rajeev Aurora, Brittani Lubeck, Aarushi Choudhari

Institution: Saint Louis University

Language: English

Topic: Genetics, Aging, and Longevity in Model Organisms

Subfield: Aging

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7161089581

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