Work

Oesophageal mucormycosis managed with antifungal therapy alone with PET/CT for monitoring treatment response: a case report and a review of the literature

Year: 2026

Type: article

Abstract: Oesophageal mucormycosis is an uncommon life-threatening opportunistic fungal infection usually managed with antifungal therapy and aggressive surgical debridement. We describe a 54-year-old male who developed oesophageal mucormycosis 3 months post-allograft for multiply-relapsed leukaemia. Surgery was not performed due to prohibitive perioperative risk. He received 6 weeks of intravenous Liposomal Amphotericin B followed by long-term isavuconazole. Serial endoscopy and PET/CT imaging demonstrated resolution of infection to 7 months post-transplant where he died from relapsed leukaemia. We demonstrate that antifungal therapy alone may be efficacious where surgery is contraindicated and highlight the utility of PET/CT imaging for staging and monitoring this disease.

Source: Medical Mycology Case Reports

DOI: 10.1016/j.mmcr.2026.100797

Authors: Ethan X. Tan, Brennan Collis, Natasha Holmes, Julie Lokan, Andrew Grigg

Institutions: Austin Hospital, Austin Health, The University of Melbourne

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $650