Sex and ovarian hormone status shape baseline cardiovascular physiology in Sprague Dawley rats
Year: 2026
Type: article
Abstract: Sex differences in cardiovascular physiology are often interpreted without accounting for growth-dependent scaling and cohort standardization. Here, we show that normalization strategy, estrogen status, and the timing of ovarian hormone loss interact critically to shape cardiac structure and passive myocardial mechanics in rats. Notably, early estrogen loss increases right ventricular stiffness independent of hemodynamic load, underscoring the importance of experimental design in interpreting sex-specific phenotypes.
Institution: University of California San Diego
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1935086282, G250627029, G2635291395, Ventriculo-vascular coupling in PAH ' Significance of large-vessel remodeling on cardiac and pulmonary vascular function, CAREER: Mechanical and Structural Adaptations of Blood Vessels in Pulmonary Arterial Hypertension, G4863127877, Training in Multi-scale Analysis of Biological Structure and Function
OpenAlex ID: W7161194172