Collaborative Research: A multi-fidelity computational framework for vascular mechanobiology in SimVascular
Year: 2025
Type: conference-abstract
Abstract: SimVascular is a comprehensive, open-source software platform for cardiovascular modeling, offering a complete pipeline for image-based anatomical reconstruction and blood flow simulation. While the framework excels in acute blood flow predictions, there remains a critical need for tools that link biomechanics with mechanobiology to study long-term mechanistic adaptations of the cardiovascular system. Mechanobiological processes such as vascular growth and remodeling, autoregulation, and perfusion occur in distal vessels and microvasculature, necessitating the construction of full-scale vascular networks. This work presents an open-source algorithm for generating synthetic, space-filling vascular networks beyond image resolution limits. The method is 230 times faster than standard vascular generation approaches, enables usage in arbitrarily complex geometries, from small-scale tissue constructions to full organ domains, and produces watertight networks suitable for both computational fluid dynamics (CFD) simulation and 3D biofabrication. These advancements expand SimVascular’s capabilities beyond multiphysics simulation, enabling multiscale modeling and design of engineered organ-scale tissues with applications in patient-specific replacement of damaged or diseased organs.
Source: Figshare
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
Awards: G4780791902, G8885416509
OpenAlex ID: W7161231856