Inside Front Cover: Proximity‐Induced Transfer of a Mass Tag Enables Direct Profiling of Active Matrix Metalloproteases (Angew. Chem. Int. Ed. 24/2026)
Year: 2026
Type: paratext
Abstract: Ionized by the MALDI laser, CHCA-labelled peptide signatures of active proteases appear as bright signals in mass spectrometry, revealing distinct activity fingerprints and functional biomarker readouts. This proximity-induced, mass-encoded activity-based protein profiling (ABPP) approach enables direct, multiplexed, and quantitative detection of enzyme activity in complex proteomes without enrichment or purification. More in Research Article e23132, Gilles Subra, Sonia Cantel, Laurent Devel, and co-workers. Image design by Monika Kaminska.
Authors: Lomane Berthy, Ugo Pasco, Mylene Sejalon‐Cipolla, Pierrick Bruyat, Monika Kaminska, Carole Malgorn, Fabrice Beau, Manca Osolin, Metka Novak, Barbara Breznik, Dimitris Georgiadis, Isabelle Correia, Emeline Groult, Olivier Lequin, Sarah Bregant, Yves‐Marie Pers, Daniele Noel, Robert Thai, Gilles Subra, Sonia Cantel, Laurent Devel
Institutions: Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Université Paris-Saclay, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, CEA Paris-Saclay, Médicaments et Technologies pour la Santé, École Nationale Supérieure de Chimie de Montpellier, Centre National de la Recherche Scientifique, Université de Montpellier, Institut des Biomolécules Max Mousseron, National Institute of Biology, Inserm, Centre Hospitalier Universitaire de Montpellier, Institute for Regenerative Medicine & Biotherapy, University of Ljubljana, National and Kapodistrian University of Athens, École Normale Supérieure - PSL, Sorbonne Université, Chimie Physique et Chimie du Vivant
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W7161251048