Work

Asynchronous dual-Lissajous scanning for shuffle-coded compressive Raman imaging

Year: 2026

Type: article

Abstract: We present an asynchronous Lissajous scanning strategy that independently controls the excitation and scattering projection paths, enabling shuffle‑coded compressive confocal Raman imaging. This scanning strategy projects scattered photons onto the spectrometer entrance in a randomly interleaved manner without sacrificing scanning speed. In contrast to the step-and-settle scanning used in earlier SIRI implementations, the continuous Lissajous trajectories enable seamless spatial sampling with a substantially reduced dwell time of the focused laser spot at each sampling point, thereby mitigating photobleaching and photodamage. Furthermore, compared to single-Lissajous scanning of laser beam for undersampling-based compressive hyperspectral imaging, the dual-Lissajous approach achieves significantly improved reconstruction fidelity in both spatial and spectral domains. The feasibility of the proposed method is demonstrated through numerical simulations and experimental studies involving microplastics and single yeast cells.

Source: Optics & Laser Technology

DOI: 10.1016/j.optlastec.2026.115527

Authors: Bingyu Zhang, Guiwen Wang, Hang Yuan, Pengfei Zhang

Institutions: Tianjin University, Guangxi Academy of Sciences

Language: English

Topic: Spectroscopy Techniques in Biomedical and Chemical Research

Subfield: Biophysics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,230

Funder: National Natural Science Foundation of China