Work

Achieving Diverse Functionalizations of Electron‐Deficient Aryl Halides via Carbonate‐Mediated Electron‐Donor–Acceptor Complexes

Year: 2026

Type: article

Abstract: Aryl halides are excellent precursors for functional group interconversion due to their malleability and diversity. They are also among the most common building blocks due to their use in cross-coupling reactions. Traditional methodologies for activating these motifs make use of expensive precious metals, such as palladium, and often require the use of complex and even more expensive ligands. Electron-donor-acceptor complexes have recently gained attention as a new photo-induced approach for the activation of various molecular motifs, including aryl halides. Herein, further extension of these methodologies led to the development of a straightforward and simple protocol that uses inexpensive carbonate bases for the activation of electron-deficient aryl iodides and bromides. The procedure was employed for the arylation, dehalogenation, deuteration, chalcogenation, and borylation of aryl halide starting materials.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.70519

Authors: Krishnakumar Sachidanandan, Cole Stenftenagel, Athul Joshy, Sébastien Laulhé

Institution: Indiana University Indianapolis

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,330

Funders: National Science Foundation, National Institutes of Health, National Institute of General Medical Sciences