Work

Short‐Term Daily Oral Administration of Cannabidiol Does Not Impact Rebound Tonometry Intraocular Pressure or Schirmer Tear Test Values in Healthy Adult Horses

Year: 2026

Type: article

Abstract: OBJECTIVE: To assess the effect of orally administered cannabidiol (CBD) on TonoVet measured intraocular pressure (IOP) and Schirmer tear test I (STT) in horses. ANIMAL STUDIED: Horse. PROCEDURE: This was a masked, randomized, balanced cross-over study of six healthy adult horses. Horses were randomly assigned and received 3 mg/kg CBD in sesame oil or volume matched placebo by mouth once daily for three days. Baseline and daily 4-, 12-, and 24-h post treatment IOPs were measured in triplicate without sedation or eyelid akinesia. Baseline and 24-h post final (day 3) treatment STTs were measured without sedation or eyelid akinesia. After a five-week washout period, horses received the alternate treatment, and measurements were repeated as above. RESULTS: Overall, there were no clinically relevant differences in IOP with CBD administration. Irrespective of treatment, IOPs were significantly higher in the second treatment period (p = 0.009). There were no differences in STT with CBD administration. CONCLUSION: Oral CBD administration in healthy horses does not impact rebound tonometry IOP or STT measurements.

Source: Veterinary Ophthalmology

DOI: 10.1111/vop.70188

Authors: Kathryn Diehl, Colleen Sheridan, Rachel Reed

Institution: University of Georgia

Language: English

Topic: Cannabis and Cannabinoid Research

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,860