Epidemiological, Clinical and Allergic Profile of Patients With Dyshidrotic Eczema (Acute and Recurrent Vesicular Dermatitis): Evaluation of the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy ( REIDAC )
Year: 2026
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Dyshidrotic eczema (DE), also termed acute and recurrent vesicular dermatitis, is a vesicular clinical pattern of hand eczema (HE) with heterogeneous aetiologies. OBJECTIVES: To characterise the clinical-allergological profile of patients with DE and to compare it with non-DE HE subtypes. METHODS: A multicentre, retrospective, observational study was conducted using data from the Spanish Contact Dermatitis Registry (2019-2024). RESULTS: Of 4378 patients with HE, 559 were diagnosed with DE. A longer median disease duration (24 vs. 14 months) and more frequent palmoplantar involvement (16% vs. 7%) were observed in DE compared with non-DE HE. At least one positive patch test was identified in 43% of DE versus 52% in non-DE HE. Although overall sensitisation patterns were largely comparable, DE showed lower sensitisation rates to 2-HEMA, carba mix and thiuram mix. Occupational factors were less frequently implicated in DE (9% vs. 29%) compared with non-DE HE. CONCLUSIONS: Despite a high overall frequency of contact allergen sensitisation, the pattern of findings suggests that the dyshidrotic phenotype may follow a clinical course less dependent on external or occupational triggers, pointing towards a relatively greater contribution of endogenous factors compared with other HE subtypes.
Source: Contact Dermatitis
DOI: 10.1111/cod.70184
Authors: Araceli Sánchez‐Gilo, Enrique Gómez de la Fuente, Ana M. Giménez‐Arnau, Juan Francisco Silvestre‐Salvador, Pedro Mercader‐García, Tatiana Sanz‐Sánchez, Violeta Zaragoza‐Ninet, Susana Córdoba‐Guijarro, Javier Miquel‐Miquel, Ricardo González‐Pérez, Inmaculada Ruiz‐Gonzalez, Esther Serra‐Baldrich, José Manuel Carrascosa‐Carrillo, Francisco Javier Ortiz de Frutos, Mercedes Rodríguez‐Serna, María Elena Gatica‐Ortega, Carmen Paredes‐Suárez, Francisco J. Navarro‐Triviño, Pablo Chicharro, María Antonia Pastor‐Nieto, Marta Andreu Barasoain, José‐Juan Pereyra‐Rodríguez, Gemma Melé‐Ninot, Paloma Sánchez‐Pedreño Guillén, Marta Elosua‐González, Miguel Ángel Descalzo, Ignacio García‐Doval, Raquel Barba‐Martín, Leopoldo Borrego
Institutions: Universidad Rey Juan Carlos, Hospital Universitario Rey Juan Carlos, Hospital Universitario Ramón y Cajal, Universitat Pompeu Fabra, Hospital Del Mar, Hospital del Mar Research Institute, Hospital General Universitario de Alicante Doctor Balmis, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Hospital General Universitario Morales Meseguer, Hospital Universitario Infanta Sofía, Universidad Europea de Madrid, Hospital General Universitario De Valencia, Hospital Universitario de Fuenlabrada, Hospital Arnau de Vilanova, University of the Basque Country, Hospital Universitario Araba, Complejo Asistencial Universitario de León, Hospital de Sant Pau, Hospital Universitari Germans Trias i Pujol, Hospital Universitario 12 De Octubre, Hospital Universitari i Politècnic La Fe, Complejo Hospitalario Universitario de Toledo, Hospital Universitario de Toledo, Complejo Hospitalario Universitario de Santiago, Hospital Universitario de La Princesa, Hospital Universitario de Guadalajara, Hospital Universitario Fundación Jiménez Díaz, Hospital Universitario Fundación Alcorcón, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Hospital Universitari Sagrat Cor, IDCQ Hospitales y Sanidad, S.L.U., Hospital Universitario Virgen de la Arrixaca, Hospital Universitario Puerta de Hierro Majadahonda, Spanish Academy of Dermatology and Venereology, University Hospital Complex Of Vigo, Universidad de Las Palmas de Gran Canaria, Hospital Universitario Insular de Gran Canaria
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,060
OpenAlex ID: W7161502606