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An unusual case of burst suppression electrographic pattern following intrathecal baclofen overdose in critical care: a case report

Year: 2026

Type: article

Abstract: Baclofen is a gamma-aminobutyric acid (GABA)-B receptor agonist used to treat neurological spasticity. Several cases of baclofen intoxication have been reported with neurological symptoms. While numerous reports describe oral baclofen toxicity, the neurological consequence of intrathecal overdose remain poorly characterised. We describe an electroencephalogram (EEG) post-anoxic encephalopathy pattern following intrathecal BACLOFEN injection to treat spasticity in an intensive care unit in September 2024.

Source: European Journal of Anaesthesiology Intensive Care

DOI: 10.1097/ea9.0000000000000115

Authors: Nory Elhadjene, Hugo Soulier

Institutions: Laboratoire Interuniversitaire de Biologie de la Motricité, Centre Hospitalier Universitaire de Saint-Étienne, Université Jean Monnet

Language: English

Topic: Botulinum Toxin and Related Neurological Disorders

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7161562329

FWCI:

Cites: 9

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