Work

Feasibility of co-polarizing ¹³C-pyruvate and ¹³C-tert-butanol for simultaneous metabolic and perfusion imaging

Year: 2026

Type: article

Abstract: Altered metabolism and perfusion are hallmarks of numerous diseases, yet simultaneous evaluations in vivo remain limited. We present a dual-purpose hyperpolarized probe combining [1-¹³C]pyruvate and ¹³C- tert -butyl alcohol ( 13 C-TBA) for concurrent metabolic and perfusion imaging. An optimized formulation produced high polarizations with short build-up times. In vivo imaging in healthy and tumor-bearing rats demonstrated robust signals of TBA and pyruvate metabolism. This co-polarized dual probe offers strong preclinical and translational potential.

Source: npj Imaging

DOI: 10.1038/s44303-026-00172-9

Authors: Karen Dos Santos, Samuel R Calos, Qianhui Dou, Atsushi M. Takahashi, Leo L. Tsai, Aaron K. Grant, Yi-Fen Yen

Institutions: Harvard University, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Beth Israel Deaconess Medical Center

Language: English

Topic: Advanced NMR Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,790

Funders: Massachusetts General Hospital, National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering

Awards: Carbon-13 Polarizer for Metabolic MR Imaging, Next generation metabolic imaging of the effect of exercise on mitochondrial function in Alzheimer's disease, Upgrade to 3 Tesla MRI scanner for brain imaging at MIT, Console Upgrade for 4.7T PET-MRI Preclinical Scanner, Hyperpolarized MR-PET for evaluating mitochondrial function and availability in an Alzheimers Disease Model, Plug-and-play Hyperpolarized MRI of Metabolism on Clinical Scanners

OpenAlex ID: W7161570045

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