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Pericapsular nerve group (PENG) block at 10 mL vs. 20 mL for postoperative analgesia after total hip arthroplasty: a randomized controlled trial

Year: 2026

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: BACKGROUND: The pericapsular nerve group (PENG) block is increasingly used for analgesia in hip-related procedures. However, the optimal local anesthetic volume remains unclear. This randomized non-inferiority trial aimed to compare the analgesic efficacy of 10 mL versus 20 mL PENG block after total hip arthroplasty, hypothesizing that the lower volume would provide non-inferior analgesia. METHODS: In this single-center randomized controlled non-inferiority trial, 50 patients undergoing hip replacement surgery received an ultrasound-guided PENG block with 0.25% bupivacaine, either 20 mL (n = 25) or 10 mL (n = 25). Postoperative analgesia was provided using morphine patient-controlled analgesia. Pain scores at rest and during movement were assessed at predefined time points up to 24 h postoperatively. The primary outcome was the NRS pain score at rest 1 h after surgery. Secondary outcomes included opioid consumption, quadriceps muscle strength, postoperative nausea and vomiting, and patient satisfaction. RESULTS: There were no significant differences between groups in opioid-related side effects, quadriceps muscle weakness, patient satisfaction, or length of hospital stay. Non-inferiority analysis demonstrated that the median differences in NRS scores between groups remained within the predefined non-inferiority margin of 1 NRS point at all assessment time points. Non-inferiority of the 10 mL PENG block was confirmed for the primary outcome. CONCLUSIONS: A 10 mL PENG block provides postoperative analgesia non-inferior to a 20 mL volume without increasing opioid consumption or motor weakness, suggesting that lower volumes may be sufficient and potentially safer after total hip arthroplasty. TRIAL REGISTRATION: ClinicalTrials.gov, NCT06166602. Registered on December 04, 2023. Retrospectively registered (study start date July 30, 2023).

Source: BMC Anesthesiology

DOI: 10.1186/s12871-026-03923-8

Authors: Gökçe Aliş, Mesure Gül Nihan Özden, Rasim Onur Karaoğlu

Institutions: Sancaktepe Şehit Prof. Dr. İlhan Varank Eğitim ve Araştırma Hastanesi, Ministry of Health, Bağcılar Eğitim ve Araştırma Hastanesi

Language: English

Topic: Anesthesia and Pain Management

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190