Work

Understanding the Interplay Between Obesity and Cancer: From Mechanisms to Therapeutic Opportunities

Year: 2026

Type: article

Abstract: Obesity has risen to the forefront of global public health challenges, particularly due to its association with several chronic diseases. Its association with cancer has attracted significant research interest. The relationship between obesity and cancer is complex and profoundly influences tumorigenesis, cancer progression, metastasis, and therapeutic efficacy. This review provides the molecular basis of these interactions, elucidating how obesity triggers changes in the tumor microenvironment, disrupts metabolic pathways, and promotes inflammation. These factors facilitate cancer development and reduce the efficacy of treatments. By unraveling these mechanisms, we aim to identify therapeutic strategies that could mitigate obesity's detrimental effects on cancer outcomes and contribute to the development of more effective strategies for managing obesity-related cancers.

Source: Cancers

DOI: 10.3390/cancers18101620

Authors: Sunsook Hwang, Byungjoo Kim, Seungyeon Yang, Seung Min Jeong

Institutions: Konkuk University, Catholic University of Korea

Language: English

Topic: Cancer Risks and Factors

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499