Work

The Shape of Things to Come: α-Helical Membrane Protein Folding on the Ribosome

Year: 2026

Type: review

Abstract: membrane protein folding. The mechanisms driving membrane protein folding remain elusive, largely due to the limited availability of approaches that can probe these processes both in real-time and in their native context. Here, we discuss recent progress in uncovering how membrane proteins fold during synthesis and insertion, and highlight how established and emerging biophysical and structural tools are beginning to resolve cotranslational events with greater mechanistic detail than has been previously possible. Together, these advances are reshaping our understanding of membrane protein biogenesis far beyond traditional refolding models.

Source: Chemical Reviews

DOI: 10.1021/acs.chemrev.6c00236