Work

Comprehensive Transcriptomic Profiling of Nonatopic Prurigo Nodularis in Korean Patients Reveals Il-22–driven Epidermal Stress and Neuro-immuno-fibrotic Remodelling

Year: 2026

Type: article

Abstract: Prurigo nodularis (PN) is a chronic pruritic dermatosis with incompletely defined pathogenesis, and molecular data from East Asian populations are limited. We characterized the transcriptomic signatures of non-atopic PN in Korean patients to identify pathways linked to chronic itch and lesion persistence. RNA sequencing was performed on lesional and non-lesional skin from 17 PN patients and normal skin from 11 controls, followed by differential expression, functional enrichment, and correlation analyses. Lesional PN skin showed distinct transcriptional signatures with upregulation of Th22/IL-22-related genes and IL-22-inducible epidermal stress markers (S100A7/A8/A9, SERPINB4, HRNR), along with keratinization genes (KRT6C, KRT16, KRT17). Itch severity correlated strongly (Spearman's ρ>0.7) with IL-22-inducible stress genes, IL4R, profibrotic mediators (WNT5A), JAK-STAT regulators (JAK3, SOCS1/3), neuromodulatory/epidermal-neural genes (TRPV3), and senescence markers (CDKN1A, CXCL8, PLAUR). Non-lesional skin showed intermediate expression patterns, consistent with subclinical inflammation. Despite the modest sample size and single-ethnicity design, these findings indicate that non-atopic PN in Korean patients is characterized by IL-22-driven epidermal stress, fibroblast remodelling, neuroimmune signalling, and senescence programsprogrammes, highlighting therapeutic targets including IL-31RA, IL-4Rα/JAK1, antifibrotic and senescence-directed pathways.

Source: Acta Dermato Venereologica

DOI: 10.2340/actadv.v106.adv-2025-0169

Authors: Hei Sung Kim, Yoon-Seob Kim, Gil Yosipovitch

Institutions: The Catholic University of Korea Incheon St. Mary's Hospital, Catholic University of Korea, The Catholic University of Korea Bucheon St. Mary's Hospital, University of Miami

Language: English

Topic: Dermatology and Skin Diseases

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,725