The Metabolome of the Ocotea spp.: From Biosynthetic Aspects to Bioactive Chemical Scaffolds by Integrating the Genus Chemical Database ( Ocotea DB)
Year: 2026
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide The genus Ocotea is a significant source of bioactive agents within the Lauraceae, yet it remains underexplored. Despite its ethnomedicinal relevance and chemical diversity, Ocotea species remain taxonomically challenging as they belong to the multifaceted “Ocotea complex”, a phylogenetically unresolved group. Moving beyond previous literature Ocotea surveys, this review provides the first curated, genus-specific data set of both volatile and nonvolatile specialized metabolites. Covering research articles from 1830 to 2025, this review provides the most comprehensive synthesis to date, documenting 984 unique chemical compounds across 115 species. This effort culminated in the construction of the Ocotea Chemical Database ( Ocotea DB), a novel digital resource created to streamline the genus’s chemical diversity for the global scientific community. Furthermore, it presents current knowledge of biosynthetic routes leading to key bioactive scaffolds, including aporphinoid and benzylisoquinoline alkaloids, lignoids, glycosylated flavonoids, and a diverse array of terpenoids, while addressing the stereochemical and structural intricacies unique to the genus. This review lays a robust foundation to drive future Ocotea -focused bioprospecting studies and guides research in the fields of natural products, chemophenetics, metabolomics, and medicinal chemistry regarding the Ocotea species, its chemical scaffolds, and specialized metabolites.
Source: Journal of Natural Products
Authors: Albert Katchborian-Neto, Karen de Jesus Nicácio, Paula Carolina Pires Bueno, Miller Santos Ferreira, Matheus Fernandes Alves, Daniele de Oliveira Silva, Wanderleya Toledo dos Santos, Marina de Monroe Gonçalves, Ana Claudia Chagas de Paula, Danielle Ferreira Dias, Marisi G. Soares, RuAngelie Edrada-Ebel, João Henrique G. Lago, Daniela Aparecida Chagas-Paula
Institutions: Universidade Federal de São Carlos, Universidade Federal de Alfenas, Universidade Federal do ABC, Universidade Federal de Mato Grosso, Leibniz Institute of Vegetable and Ornamental Crops, Friedrich Schiller University Jena, Universidade Federal de Juiz de Fora, University of Strathclyde
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Awards: G1013140573, G1207375514, G1454113806, G1798140553, G2106507702, G22113365, AVANÇO DA PESQUISA E PÓS-GRADUAÇÃO NA UNIFAL-MG ATRAVÉS DA CRIAÇÃO DE REDES DE COLABORAÇÃO INTERNACIONAIS, G2879888585, G29316538, G347430574, G3594283485, G3690646728, G4014156985, G4758110241, G4843951425, FORTALECIMENTO DA INTERNACIONALIZAÇÃO ATRAVÉS DE REDES DE COLABORAÇÃO INTERNACIONAIS NA PESQUISA E PÓS-GRADUAÇÃO DA UNIFAL-MG, METABOLÔMICA DE CULTIVARES DE CAFÉ SUSCETÍVEIS E RESISTENTES À FERRUGEM (HEMILEIA VASTATRIX) E ANÁLISE DE VIABILIDADE ECONÔMICA: RELAÇÕES DA COMPOSIÇÃO QUÍMICA COM POTENCIAL ECONÔMICO, PERFIS DE RESISTÊNCIA E QUALIDADE SENSORIAL, G6579546856, G6807003123, G7199106475, G7973128220, METABOLÔMICA, ISOLAMENTO DE SUBSTÂNCIAS DE ESPÉCIES VEGETAIS E SEMI-SÍNTESE DE DERIVADOS COM AÇÃO ANTI-INFLAMATÓRIA E DE NEUROPROTEÇÃO EM MODELO EXPERIMENTAL DA DOENÇA DE PARKINSON, G871200192
OpenAlex ID: W7161640167