Work

Decidual aging in recurrent pregnancy Loss: from regulating networks to therapeutic interventions

Year: 2026

Type: article

Abstract: .The uterine decidua is a key component of the maternal-fetal interface, and its senescence may be an important contributing factor to recurrent pregnancy loss (RPL). Decidual senescence disrupts gestational homeostasis via cell cycle arrest, immune imbalance, and metabolic reprogramming, thereby potentially contributing to RPL. This review offers a new paradigm for understanding RPL etiology, with significant clinical value for improving reproductive outcomes.

Source: npj Aging

DOI: 10.1038/s41514-026-00407-4