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Myocardial YBX1 is dispensable for cardiac development and function

Year: 2026

Type: article

Abstract: loss-of-function mouse model, addressing limitations of prior RNA interference (RNAi) approaches. Global YBX1 deletion causes embryonic lethality with severe cardiac malformations, whereas cardiomyocyte-specific deletion results in only transient embryonic noncompaction that resolves with normal adult heart structure and function. Cardiac function remained preserved for up to 11 mo, and although fibrosis-related genes were upregulated, no overt fibrotic phenotype was observed, supporting cardiomyocyte-targeted YBX1 reduction as a potentially safe therapeutic strategy.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00135.2026

Authors: Elise V. Stanley, Zhijie Han, Reaghan Sassower, Chao Gao, Chase W. Kessinger, Tongbin Wu

Language: English

Topic: Congenital heart defects research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7161681876

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Cites: 46

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