Work

Neonatal Hypoglycemia: A Systematic Review of International and Local Clinical Guidelines with Clinical Implications

Year: 2026

Type: review

Abstract: Background/Objectives: Neonatal hypoglycemia is one of the most common metabolic disturbances in the first 24–72 h of life. Despite its frequency, international and local guidelines differ regarding screening strategies, operational thresholds, and escalation pathways. This study is a systematic comparative review of international and local clinical guidelines regarding neonatal hypoglycemia management. Methods: We performed a systematic review of major guideline frameworks (AAP, BAPM, PES, CPS, Te Tohu Waihonga New Zealand, and Australian state-based guidance) and compared recommendations for risk factors, screening, treatment thresholds, and NICU admission. Results: All guidelines recommended targeted screening of at-risk neonates and immediate treatment of symptomatic hypoglycemia. However, there was no universal agreement on timing of the first blood glucose (BG) measurement, screening frequency, or minimum blood glucose threshold for initiating therapy during the transitional period. Contemporary guidelines endorse 40% oral dextrose gel as first-line therapy in selected cases. Conclusions: Despite numerical differences, guidelines converge on core management principles. Further comparative studies are required to define standardized intervention thresholds and optimal measurement strategies.

Source: Journal of Clinical Medicine

DOI: 10.3390/jcm15103921

Authors: Camelia Rusu, Melinda Matyas, Boris W. Kramer, Florica Ramona Dorobanțu, Alin Bodog

Institutions: University of Oradea, Iuliu Hațieganu University of Medicine and Pharmacy, Poznan University of Medical Sciences

Language: English

Topic: Neonatal Health and Biochemistry

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,137